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Loss of life (also reffered to as "Loss of HP" & LoL) is an effect which reduces a champion's current HP. As is commonly stated, Loss of life is not considered to be damage, despite reducing HP & appearing similar in the interface. This means abilities such as Drive are separate from any ability/condition which mentions "damage". For example, loss of life does not get reduced by Impervious.

Loss of life will bypass all clauses that use the term damage as a trigger .

Deflect and Impervious are both abilities that use "damage" as a trigger for the abillity to take effect.  Thus, LoL damage will not trigger these abilities.

Loss of life damage does not currently bypass defense .  Defense currently reduces all sources of HP reduction, that lack a clause bypassing it.

Loss of Life Sources

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