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A champion's Defense affects how much damage or HP Loss is subtracted from incoming attacks. Thus if an attacker's damage is 12 and the target's defense is 2, the attack will deal 10 damage. (Note that other abilities such as Evasive and Tough can affect how much damage is dealt, but they will not affect HP loss like defense)

In addition, realize that several abilities ignore defense, as stated in the ability's rule text. For example, all cones such as Acid Bomb and Frost Cone ignore defense.

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